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EnglishIt is well documented that dysregulation of microRNAs is a hallmark of human cancers. Thus, this family of small non-coding regulatory molecules represents an excellent source of sensitive biomarkers. Unique microRNAs expression profiles have been associated with different types and subsets of gastrointestinal tumors including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). GEP-NETs are a heterogeneous group of epithelial neoplasms with neuroendocrine differentiation. At present, early detection and surgical resection of GEP-NETs represent the best chance for a cure. Thus, clinically useful biomarkers for GEP-NETs that strongly correlate with early detection are urgently needed. The purpose of this review is to summarize the role of miRNAs in GEP-NET carcinogenesis and their possible use as novel diagnostic, prognostic and predictive biomarkers.
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| Titolo: | Clinical application of microRNA testing in neuroendocrine tumors of the gastrointestinal tract | |
| Autori: | ||
| Data di pubblicazione: | 2014 | |
| Rivista: | ||
| Handle: | http://hdl.handle.net/11586/250765 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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