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EnglishThe peptide GSFSIQYTYHV derived from human semenogelin I forms a transparent hydrogel through spontaneous self-assembly in water at neutral pH. Linear rheology measurements demonstrate that the gel shows a dominating elastic response over a large frequency interval. CD, fluorescence and FTIR spectroscopy and cryo-TEM studies imply long fibrillar aggregates of extended beta-sheet. Dynamic light scattering data indicate that the fibril lengths are of the order of micrometers. Time-dependent thioflavin T fluorescence shows that fibril formation by GSFSIQYTYHV is a nucleated reaction. The peptide may serve as basis for development of smart biomaterials of low immunogenicity suitable for biomedical applications, including drug delivery and wound healing.
| Titolo: | A peptide from human semenogelin i self-assembles into a pH-responsive hydrogel | |
| Autori: | ||
| Data di pubblicazione: | 2015 | |
| Rivista: | ||
| Handle: | http://hdl.handle.net/11586/249696 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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