Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Bertolino A.Funding Acquisition
;Papalino M.Membro del Collaboration Group
;Pergola G.Membro del Collaboration Group
;
2019-01-01
Abstract
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.File in questo prodotto:
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Kaufmann 2019 - brain age genetics.pdf
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