Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Common brain disorders are associated with heritable patterns of apparent aging of the brain

Bertolino A.
Funding Acquisition
;
Papalino M.
Membro del Collaboration Group
;
Pergola G.
Membro del Collaboration Group
;
2019

Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/242992
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