Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Bertolino A.Funding Acquisition
;Papalino M.Membro del Collaboration Group
;Pergola G.Membro del Collaboration Group
;
2019
Abstract
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Kaufmann 2019 - brain age genetics.pdf
non disponibili
Tipologia:
Documento in Versione Editoriale
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
8.17 MB
Formato
Adobe PDF
|
8.17 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
Kaufmann .pdf
accesso aperto
Tipologia:
Documento in Pre-print
Licenza:
Creative commons
Dimensione
154.16 kB
Formato
Adobe PDF
|
154.16 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
