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EnglishWe have read with great interest the article by Stone et al because it is a strong alert to physicians to focus their attention toward the increasing role of drug excipients in the genesis of immediate-type reactions, which can be genuinely IgE mediated too. Furthermore, the authors demonstrated that even polysorbates may be responsible for IgE-mediated reactions because of their cross-reactivity with the polyethylene glycols (PEGs) caused by common chemical epitope, whereas it had been previously suggested that polysorbates caused nonimmunologic hypersensitivity. PEGs or macrogols are linear or branched polymers with repeating ethylene oxide subunits and different molecular weights, ranging from 200 g/mol up to 10,000 g/mol according to the length of their chains.3 Recently, a high prevalence of pre-existing anti-PEG IgM and IgG antibodies have been detected in the plasma of healthy donors.
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| Titolo: | Polyethylene glycols and polysorbates: Two still neglected ingredients causing true IgE-mediated reactions |
| Autori: | |
| Data di pubblicazione: | 2019 |
| Rivista: | |
| Abstract: | We have read with great interest the article by Stone et al because it is a strong alert to physicians to focus their attention toward the increasing role of drug excipients in the genesis of immediate-type reactions, which can be genuinely IgE mediated too. Furthermore, the authors demonstrated that even polysorbates may be responsible for IgE-mediated reactions because of their cross-reactivity with the polyethylene glycols (PEGs) caused by common chemical epitope, whereas it had been previously suggested that polysorbates caused nonimmunologic hypersensitivity. PEGs or macrogols are linear or branched polymers with repeating ethylene oxide subunits and different molecular weights, ranging from 200 g/mol up to 10,000 g/mol according to the length of their chains.3 Recently, a high prevalence of pre-existing anti-PEG IgM and IgG antibodies have been detected in the plasma of healthy donors. |
| Handle: | http://hdl.handle.net/11586/242693 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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