Bodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies

Monagle, Paul; Lensing, Anthonie W A; Thelen, Kirstin; Martinelli, Ida; Male, Christoph; Santamaría, Amparo; Samochatova, Elena; Kumar, Riten; Holzhauer, Susanne; Saracco, Paola; Simioni, Paolo; Robertson, Jeremy; Grangl, Gernot; Halton, Jacqueline; Connor, Phillip; Young, Guy; Molinari, Angelo C; Nowak-Göttl, Ulrike; Kenet, Gili; Kapsa, Stefanie; Willmann, Stefan; Pap, Akos F; Becka, Michael; Twomey, Teresa; Beyer-Westendorf, Jan; Prins, Martin H; Kubitza,; Dagmar Collaborators: Monagle, P; Robertson, J; Grangl, G; Male, C; Streif, W; Carniero, J; Logetto, S; Brandao, L; Halton, J; Amedro, P; Bonnet, D; Beyer-Westendorf, J; Dietrich, S; Holzhauer, S; Nowak-Göttl, U; Kallay, K; Kenet, G; Revel-Vilk, S; Tamary, H; Giordano, P; Abbattista, M; Artoni, A; Molinari, Ac; Saracco, P; Simioni, P; Tormene, D; Ono, H; Te Loo MW,; Van Ommen, H; Veening, Ma; Suiker, Mh; Peters, M; Samochatova, E; Shamardina, A; Novgorod, N; Zubarovskaya, L; Dasi, Ma; Elorza, M; Santamaria, A; Sánchez-Luna, M; Albisetti, M; Grunt, S; Kavakli, K; Biss, T; Connor, P; Williams, M; Acharya, S; Bhat, R; Kearney, S; Kumar, R; Patel, K; Rajpukar, M; Schwartz, Jh; Vik, T; Wynn, T; Yee, Dl; Young, G

doi:10.1016/S2352-3026(19)30161-9

Rivaroxaban has been shown to be efficacious for treatment of venous thromboembolism in adults, and has a reduced risk of bleeding compared with standard anticoagulants. We aimed to develop paediatric rivaroxaban regimens for the treatment of venous thromboembolism in children and adolescents.

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Titolo:	Bodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies
Autori:	Monagle, Paul Lensing, Anthonie W A Thelen, Kirstin Martinelli, Ida Male, Christoph Santamaría, Amparo Samochatova, Elena Kumar, Riten Holzhauer, Susanne Saracco, Paola Simioni, Paolo Robertson, Jeremy Grangl, Gernot Halton, Jacqueline Connor, Phillip Young, Guy Molinari, Angelo C Nowak-Göttl, Ulrike Kenet, Gili Kapsa, Stefanie Willmann, Stefan Pap, Akos F Becka, Michael Twomey, Teresa Beyer-Westendorf, Jan Prins, Martin H Kubitza Dagmar Collaborators: Monagle P Robertson J Grangl G Male C Streif W Carniero J Logetto S Brandao L Halton J Amedro P Bonnet D Beyer-Westendorf J Dietrich S Holzhauer S Nowak-Göttl U Kallay K Kenet G Revel-Vilk S Tamary H GIORDANO, Paola Abbattista M Artoni A Molinari AC Saracco P Simioni P Tormene D Ono H Te Loo MW Van Ommen H Veening MA Suiker MH Peters M Samochatova E Shamardina A Novgorod N Zubarovskaya L Dasi MA Elorza M Santamaria A Sánchez-Luna M Albisetti M Grunt S Kavakli K Biss T Connor P Williams M Acharya S Bhat R Kearney S Kumar R Patel K Rajpukar M Schwartz JH Vik T Wynn T Yee DL Young G mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2019
Rivista:	THE LANCET. HAEMATOLOGY
Abstract:	Rivaroxaban has been shown to be efficacious for treatment of venous thromboembolism in adults, and has a reduced risk of bleeding compared with standard anticoagulants. We aimed to develop paediatric rivaroxaban regimens for the treatment of venous thromboembolism in children and adolescents.
Handle:	http://hdl.handle.net/11586/242087
Appare nelle tipologie:	1.1 Articolo in rivista

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