Expression of proto-oncogene C-kit and correlation with morphological evaluations in canine cutaneous mast cell tumors

Canine cutaneous mast cell tumor (MCT) is very common disease in dogs, this is more aggressive than in other species. The biologic behavior of MCT is highly variable and a more accurate prognosis for these tumors needs to performed. The proto-oncogene c-kit is known to play a critical role in development and function of mast cells (MC). The aim of this study was to evaluate the expression of immunohistochemical pattern of c-kit in MCTs and to correlate these results with MC density (MCD) and intratumoral microvessel density (MVD). Our results confirm that a more aggressive biologic behavior of canine MCT is associated with the increased c-kit expression, further suggesting a new role for c-kit, as a useful marker, in diagnostic pathology and in tumor progression. Copyright © Informa UK, Ltd.



Titolo: Expression of proto-oncogene C-kit and correlation with morphological evaluations in canine cutaneous mast cell tumors
Autori: 
PASSANTINO, Letizia
PASSANTINO, Giuseppe
CIANCIOTTA, ATTILIO
LO PRESTI, GIUSEPPE
PERILLO, Antonella
mostra contributor esterni 
Data di pubblicazione: 2008
Rivista: 
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY  
Handle: http://hdl.handle.net/11586/241669
Appare nelle tipologie:1.1 Articolo in rivista

File in questo prodotto:
Non ci sono file associati a questo prodotto.
Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11586/241669
  • Citazioni
  • PubMed Central
  • Scopus
  • WOS

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
 
 
 
Powered by IRIS-about IRIS-Utilizzo dei cookie
Logo CINECA  Copyright © 2021