Persistent nephrocalcinosis caused by neonatal subcutaneous fat necrosis: Therapeutic considerations

Neonatal subcutaneous fat necrosis (NSFN) is a transient, self-healing skin disorder, characterized by nodules and plaques caused by subcutaneous necrosis. NSFN is rarely observed in full-term newborns infants with perinatal problems, especially asphyxia. The most important NSFN complication is hypercalcemia, a common condition that can have serious consequences leading to death. In this paper we describe a case of persistent nephrocalcinosis caused by an extensive neonatal subcutaneous fat necrosis, emphasizing the symptoms to suspect hypercalcemia. We also discuss the therapeutic interventions to restore the levels of serum calcium and prevent the deposition of calcium salts.