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EnglishThe oral cavity is home to numerous viruses and micro-organisms recognized as having a role in various oral diseases as well as in infections in other parts of the body. Indeed, in general a microbial infection underlies or is believed to underlie the ample spectrum of oral diseases, from tooth enamel decay to periodontal lesions, from candidiasis to virus-induced oral squamous cell carcinomas, and bullous autoimmune oral disorders. This clinico-pathological context stresses the need of targeted therapies to specifically kill infectious agents in a complex environment such as the oral cavity, and explains the current interest in exploring peptide-based therapeutic approaches in oral and dental research. Here, we review the therapeutic potential of antimicrobial peptides such as LL-37, beta defensins, adrenomedullin, histatins, and of various peptides modulating gene expression and immuno-biological interaction(s) in oral diseases.
Peptides in Oral Diseases / LUCCHESE A; GUIDA A; PETRUZZI M; CAPONE G; LAINO L; SERPICO R. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - 18(6):6(2012), pp. 782-788.
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| Titolo: | Peptides in Oral Diseases |
| Autori: | |
| Data di pubblicazione: | 2012 |
| Rivista: | |
| Citazione: | Peptides in Oral Diseases / LUCCHESE A; GUIDA A; PETRUZZI M; CAPONE G; LAINO L; SERPICO R. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - 18(6):6(2012), pp. 782-788. |
| Abstract: | The oral cavity is home to numerous viruses and micro-organisms recognized as having a role in various oral diseases as well as in infections in other parts of the body. Indeed, in general a microbial infection underlies or is believed to underlie the ample spectrum of oral diseases, from tooth enamel decay to periodontal lesions, from candidiasis to virus-induced oral squamous cell carcinomas, and bullous autoimmune oral disorders. This clinico-pathological context stresses the need of targeted therapies to specifically kill infectious agents in a complex environment such as the oral cavity, and explains the current interest in exploring peptide-based therapeutic approaches in oral and dental research. Here, we review the therapeutic potential of antimicrobial peptides such as LL-37, beta defensins, adrenomedullin, histatins, and of various peptides modulating gene expression and immuno-biological interaction(s) in oral diseases. |
| Handle: | http://hdl.handle.net/11586/22669 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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