Oleuropein (Ole) has been claimed to mitigate cisplatin (CP) induced acute injury in kidney and liver of mice. In-vitro reactivity of hydrated CP species with Ole, and Ole metabolite hydroxytyrosol (HT) is of great interest as the preliminary step for gathering in-vivo information on the possible physiological role of the Ole/HT-cis-diammineplatinum (II) (Ole/HT-cis-DAP) conjugate.
Tandem mass spectrometry characterization of a conjugate between oleuropein and hydrated cis-diammineplatinum (II)
Ventura, Giovanni;Abbattista, Ramona;Calvano, Cosima Damiana;De Ceglie, Cristina;Losito, Ilario;Palmisano, Francesco;Cataldi, Tommaso R I
2019-01-01
Abstract
Oleuropein (Ole) has been claimed to mitigate cisplatin (CP) induced acute injury in kidney and liver of mice. In-vitro reactivity of hydrated CP species with Ole, and Ole metabolite hydroxytyrosol (HT) is of great interest as the preliminary step for gathering in-vivo information on the possible physiological role of the Ole/HT-cis-diammineplatinum (II) (Ole/HT-cis-DAP) conjugate.File in questo prodotto:
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