CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishBackground: Autologous stem cell transplantation (ASCT) generally provides good results in Hodgkin's lymphoma (HL). We studied a high-dose chemotherapy regimen based on thiotepa, etoposide and carboplatin (TECA). Methods: Fifty-eight patients with advanced HL were treated with thiotepa, etoposide and carbo platin for transplant induction. Results: The overall response rate was 79.3% (39 CR: 67.2%; and 7 PR: 12.1%); 12 patients (20.1%) were non-responders. The 5-year overall survival rate was 77.6%; five initially responder patients relapsed within the first 5 years of follow-up and underwent salvage therapy. Conclusion: The TECA conditioning regimen for ASCT in HL results in a good anti-HL effect, positive response to treatment and high 5-year overall survival rate. It was also well tolerated and did not induce excessive toxicity, suggesting that TECA may be a very useful conditioning regimen for HL. © W. S. Maney & Son Ltd 2012.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk Hodgkin's lymphoma | |
| Autori: | RIA, ROBERTO (Corresponding) | |
| Data di pubblicazione: | 2012 | |
| Rivista: | ||
| Handle: | http://hdl.handle.net/11586/223593 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Copyright © 2022