Intramuscular epinephrine as first-line treatment of anaphylaxis: Still concerns about its safety in the elderly?

Anaphylaxis is a severe condition that can affect patients of all ages. Elderly patients must be considered particularly vulnerable to severe anaphylaxis due to many risk factors such as concomitant diseases and med- ications. Intramuscular administration of epinephrine is recommended as fist-line therapy for anaphylaxis and its use should be promoted in every setting. Intramuscular epinephrine is recognized as generally safe and there are no absolute contraindications to the prescription of self-injectable adrenaline in older patients at risk of anaphylaxis.