metabolic syndrome is a cluster of cardio-metabolic risk factors associated to atherosclerosis and low-grade inflammation. Using unbiased expression screenings in peripheral blood mononuclear cells, we depict here a novel expression chart of 678 genes and 84 miRNAs controlling inflammatory, immune and metabolic responses. In order to further elucidate the link between inflammation and the HDL cholesterol pathway in metabolic syndrome (MS), we focused on the regulation of the ATP-binding cassette transporter A1 (ABCA1), a key player in cholesterol efflux.
Identification of miR-9-5p as direct regulator of ABCA1 and HDL-driven reverse cholesterol transport in circulating CD14+ cells of patients with metabolic syndrome
D'Amore, Simona;Cariello, Marica;Graziano, Giusi;Copetti, Massimiliano;Piglionica, Marilidia;Sabbà, Carlo;Palasciano, Giuseppe;Vacca, Michele
;Moschetta, Antonio
2018-01-01
Abstract
metabolic syndrome is a cluster of cardio-metabolic risk factors associated to atherosclerosis and low-grade inflammation. Using unbiased expression screenings in peripheral blood mononuclear cells, we depict here a novel expression chart of 678 genes and 84 miRNAs controlling inflammatory, immune and metabolic responses. In order to further elucidate the link between inflammation and the HDL cholesterol pathway in metabolic syndrome (MS), we focused on the regulation of the ATP-binding cassette transporter A1 (ABCA1), a key player in cholesterol efflux.File in questo prodotto:
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D’Amore Cardiovasc Res 2018.pdf
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