IL-1 Haplotype Analysis In Periodontal Disease.

Numerous studies have established statistical associations of the IL1 gene cluster polymorphisms with various inflammatory diseases. Deriving from that, the present study was intended to determine whether single-nucleotide polymorphisms (SNPs) in these gene are also associated with periodontal disease in a Linkage disequilibrium analysis. This investigation also created two haplotype blocks, both consisting of two different SNPs. Recent theoretical analyses indicate that researches with an interpretation of periodontal disease as a complex, oligogenic disorder, with IL-1 genetic variation contributing an important but not exclusive influence on disease risk. Further studies are needed to confirm these results and to understand the mechanisms behind the observed association between IL1 SNPs and periodontal disease.