Coffee may interfere with the dopaminergic transmission, and this action would possibly enhance motor activity and exert an antidyskinetic effect in Parkinsonâs disease (PD). This study aimed to see whether coffee habit could be associated with change in striatal dopamine active transporter (DAT)-single photon emission computed tomography (SPECT) imaging in PD. A total of 83 PD patients (71 current coffee drinkers and 12 never drinkers) underwent a DAT-SPECT study, using [123I]FP-CIT as radionuclide. Socio-demographic and clinical information as well as smoking habit was collected at the time of imaging acquisition. The Unified Parkinsonâs Disease Rating Scale part III was used to evaluate disease severity. On multivariable analysis, chronic coffee consumption was not associated with any significant change in striatal uptake of the radionuclide. However, the number of years patients drunk coffee was correlated with a significant increase in age at PD onset (p < 0.001). Confirming a previous report, current cigarette smoking was associated with a reduction of radionuclide uptake in putamen and caudate (p < 0.001).
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|Titolo:||Chronic coffee consumption and striatal DAT-SPECT findings in Parkinsonâs disease|
|Data di pubblicazione:||2018|
|Citazione:||Chronic coffee consumption and striatal DAT-SPECT findings in Parkinsonâs disease / Gigante, Angelo Fabio; Asabella, Artor Niccoli; Iliceto, Giovanni; Martino, Tommaso; Ferrari, Cristina; Defazio, Giovanni; Rubini, Giuseppe. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - (2018), pp. 1-5.|
|Appare nelle tipologie:||1.1 Articolo in rivista|