MicroRNAs (miRNAs) play an important role in physiological and pathological condition in human organs including kidneys. Their dysregulation on one hand can induce the onset of a specific disease and on the other hand may represent potential biomarkers for the diagnosis and therapy. In this chapter, the miRNA functions and modulations are described in several kidney diseases such as polycystic kidney disease, primary and secondary glomerulonephritides and renal transplantation. After the overview on the approach to identify and study miRNAs in nephrology, the miRNA meaning in renal physiology is illustrated. Also, the attractive perspectives of the use of miRNAs as diagnostic tools or for the specific treatment of kidney disease are taken into consideration.
MicroRNAs in Kidney Diseases
Serino, Grazia;Sallustio, Fabio;Schena, Francesco Paolo
2016-01-01
Abstract
MicroRNAs (miRNAs) play an important role in physiological and pathological condition in human organs including kidneys. Their dysregulation on one hand can induce the onset of a specific disease and on the other hand may represent potential biomarkers for the diagnosis and therapy. In this chapter, the miRNA functions and modulations are described in several kidney diseases such as polycystic kidney disease, primary and secondary glomerulonephritides and renal transplantation. After the overview on the approach to identify and study miRNAs in nephrology, the miRNA meaning in renal physiology is illustrated. Also, the attractive perspectives of the use of miRNAs as diagnostic tools or for the specific treatment of kidney disease are taken into consideration.| File | Dimensione | Formato | |
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