MC1R genotype and psoriasis: is there a link revealing a phenotypic differences?

MC1R polymorphisms are related to different degrees ofreceptor functional impairment, depending on the specific poly-morphism and number of variants.5,6As a matter of fact, ourresults show that psoriatic patients are more likely to be wt orcarriers of a single MC1R polymorphism. These data suggestthat the preserved functionality of MC1R in psoriatics can berelated to peculiar phenotypic features