The renal arterial resistance index predicts worsening renal function in chronic heart failure patients

Logo Cardiorenal Medicine Original Paper The Renal Arterial Resistance Index Predicts Worsening Renal Function in Chronic Heart Failure Patients Iacoviello M.a · Monitillo F.b · Leone M.b · Citarelli G.b · Doronzo A.c · Antoncecchi V.c · Puzzovivo A.c · Rizzo C.b · Lattarulo M.S.b · Massari F.c · Caldarola P.c · Ciccone M.M.b Author affiliations Keywords: Chronic kidney diseaseSystemic disease and the kidneyGlomerular hemodynamics Cardiorenal Med 2017;7:42-49 https://doi.org/10.1159/000448405 Abstract Get article FullText PDF Login / Register Abstract Background/Aim: The renal arterial resistance index (RRI) is a Doppler measure, which reflects abnormalities in the renal blood flow. The aim of this study was to verify the value of RRI as a predictor of worsening renal function (WRF) in a group of chronic heart failure (CHF) outpatients. Methods: We enrolled 266 patients in stable clinical conditions and on conventional therapy. Peak systolic velocity and end diastolic velocity of a segmental renal artery were obtained by pulsed Doppler flow, and RRI was calculated. Creatinine serum levels were evaluated at baseline and at 1 year, and the changes were used to assess WRF occurrence. Results: During follow-up, 34 (13%) patients showed WRF. RRI was associated with WRF at univariate (OR: 1.13; 95% CI: 1.07-1.20) as well as at a forward stepwise multivariate logistic regression analysis (OR: 1.09; 95% CI: 1.03-1.16; p = 0.005) including the other univariate predictors. Conclusions: Quantification of arterial renal perfusion provides a new parameter that independently predicts the WRF in CHF outpatients. Its possible role in current clinical practice to better define the risk of cardiorenal syndrome progression is strengthened.