During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.

A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia

GARCIA IRIGOYEN, OIHANE;MOSCHETTA, ANTONIO
2017-01-01

Abstract

During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/185621
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