Effect of neostigmine on contractility of equine pre-ovulatory follicles: an in vitro study.

In this study, the Authors investigated the modulatory effect of three single doses (106, 105, and 104 M) of neostigmine on the spontaneous contractility of equine pre-ovulatory follicles in an isolated organ bath, to establish the relationship between this acetylcholinesterase inhibitor and ovulation, in the mare. The results indicate that neostigmine increases pre-ovulatory contractility in equine follicles at each dose, but in a different manner. Indeed, the rise in contractility induced by neostigmine at 106 M and 104 M was phasic, while at 105 M it was tonic. The data obtained indicate possible implications of these drugs in the pharmacological modulation of equine ovulation.