Effects of amethopterin (MTX) on lymphoid tissue of rabbit appendix have been evaluated. The drug caused an evident depletion of lymphoid cells. This finding suggested the relevance of cytotoxicity in the mechanism of immune suppression. Discontinuation of drug treatment demonstrated a tendency toward the reorganization of the lymphoid tissue.
Immunosuppressive action and effects of amethopterin on the lymphoid tissue of the rabbit appendix
CATALANO, Giovanni;CHIUMARULO, Carmine;PALASCIANO, Nicola Antonio
1980-01-01
Abstract
Effects of amethopterin (MTX) on lymphoid tissue of rabbit appendix have been evaluated. The drug caused an evident depletion of lymphoid cells. This finding suggested the relevance of cytotoxicity in the mechanism of immune suppression. Discontinuation of drug treatment demonstrated a tendency toward the reorganization of the lymphoid tissue.File in questo prodotto:
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