Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both soluble factors mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAMDR), focusing on the role of new players, namely miRNAs, exosomes and cancerassociated fibroblasts.
Microenvironment drug resistance in multiple myeloma: Emerging new players
DI MARZO, LUCIA;DESANTIS, VANESSA;SOLIMANDO, ANTONIO GIOVANNI;RUGGIERI, SIMONA;ANNESE, TIZIANA;NICO, Beatrice;FUMARULO, Ruggiero;VACCA, Angelo;
2016-01-01
Abstract
Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both soluble factors mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAMDR), focusing on the role of new players, namely miRNAs, exosomes and cancerassociated fibroblasts.File in questo prodotto:
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Microenvironment 2016.pdf
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