Objective: To assess whether cigarette smoking interferes with dopaminergic transmission in current- and never-smoking patients with Parkinson's disease. Materials and methods: Striatal [123I]FP–CIT single photon emission computed tomography was performed in 67 patients with Parkinson's disease (35 women and 32 men aging 60.8 ± 10.1 years and staging 1.76 ± 0.5 on the Hoehn and Yahr scale). At study time, there were 13 current-smokers and 54 never-smokers. Results: Current-smokers showed a significantly lower putamen/occipital [123I]FP–CIT ratio and a non-significant trend to a lower caudate/occipital [123I]FP–CIT ratio uptake. Current-smokers were also characterized by a lower off UPDRS-III motor score. A logistic regression analysis adjusted for age, sex, disease duration, Hoehn and Yahr staging, and medication indicated a significant lower [123I]FP–CIT uptake not only in the putamen (odds ratio, 0.1; 95% confidence interval, 0.01 to 0.65; P = 0.02) but also in the caudate (odds ratio, 0.2; 95% confidence interval, 0.04 to 0.71; P = 0.015) as well as a lower UPDRS-III motor score (odds ratio, 0.9; 95% confidence interval, 0.81 to 0.99; P = 0.04) in current-smokers. Conclusions: The lower [123I]FP-CIT uptake together with the lower UPDRS-III motor score observed in our current-smokers patients with Parkinson's disease (even taking into account variables that are probably expression of dopaminergic neuron decline and treatment) would support an effect of smoking on dopaminergic synaptic mechanisms.
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|Titolo:||Smoking in Patients with Parkinson's Disease: preliminary striatal DaT-SPECT findings|
|Data di pubblicazione:||2016|
|Citazione:||Smoking in Patients with Parkinson's Disease: preliminary striatal DaT-SPECT findings / Gigante, A.F.; Defazio, G; Niccoli Asabella, A.; Superbo, M.; Ferrari, C.; Liuzzi, D.; Iliceto, G.; Livrea, P.; Rubini, G.. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - 134:4(2016), pp. 265-270.|
|Appare nelle tipologie:||1.1 Articolo in rivista|