In the present paper, we report a molecular cytogenetic study of 1q abnormalities associated with t(8;14)(q24;q32) in an adult common B acute lymphoblastic leukemia case with FAB-L2 morphology. The use of appropriate molecular cytogenetic probes allowed us to detect 13 different subclones showing heterogeneous chromosome 1 abnormalities. A complex pattern of rearrangements consisting of translocations, duplications, and inversions was observed. Breakage-fusion-bridge cycle and jumping translocation are hypothesized to have been involved in generating the large number of aberrations we detected.

Molecular cytogenetic study of instability at 1q21∼q32 in adult acute lymphoblastic leukemia

SPECCHIA, Giorgina;ALBANO, FRANCESCO;ANELLI, LUISA;ZAGARIA, ANTONELLA;PANNUNZIO, Alessandra;ARCHIDIACONO, Nicoletta;LISO, Vincenzo;ROCCHI, Mariano
2005-01-01

Abstract

In the present paper, we report a molecular cytogenetic study of 1q abnormalities associated with t(8;14)(q24;q32) in an adult common B acute lymphoblastic leukemia case with FAB-L2 morphology. The use of appropriate molecular cytogenetic probes allowed us to detect 13 different subclones showing heterogeneous chromosome 1 abnormalities. A complex pattern of rearrangements consisting of translocations, duplications, and inversions was observed. Breakage-fusion-bridge cycle and jumping translocation are hypothesized to have been involved in generating the large number of aberrations we detected.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/168962
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