Anabolic hormones are endowed with powerful actions on both the cardiovascular system and the skeletal muscle. In western countries, an age-related decline of anabolic hormones including IGF-1, testosterone and DHEA-S is extensively described, and thought to contribute to sarcopenia, visceral adiposity and osteopenia. This decline has been often referred to as somato- and andro-pause. In the last decade, a growing body of evidence has led to the hypothesis that chronic heart failure (CHF) is indeed a multiple hormone deficiency syndrome (MHDS), characterized by a reduced anabolic drive that bears relevant functional and prognostic implications. Of note, Growth Hormone (GH) or testosterone replacement therapy provides beneficial effects, particularly on exercise tolerance and well-being.

Multiple hormone deficiencies in chronic heart failure

TRIGGIANI, Vincenzo;
2015-01-01

Abstract

Anabolic hormones are endowed with powerful actions on both the cardiovascular system and the skeletal muscle. In western countries, an age-related decline of anabolic hormones including IGF-1, testosterone and DHEA-S is extensively described, and thought to contribute to sarcopenia, visceral adiposity and osteopenia. This decline has been often referred to as somato- and andro-pause. In the last decade, a growing body of evidence has led to the hypothesis that chronic heart failure (CHF) is indeed a multiple hormone deficiency syndrome (MHDS), characterized by a reduced anabolic drive that bears relevant functional and prognostic implications. Of note, Growth Hormone (GH) or testosterone replacement therapy provides beneficial effects, particularly on exercise tolerance and well-being.
File in questo prodotto:
File Dimensione Formato  
2015 Arcopinto_IntJCardiol.pdf

non disponibili

Tipologia: Documento in Versione Editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 273.81 kB
Formato Adobe PDF
273.81 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/146543
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 53
  • ???jsp.display-item.citation.isi??? 51
social impact