The immunological tolerance was described for the first time with the seminal observations made in1945 by R.D. Owen, demonstrating that cattle dizygotic twins display red cell chimerism in adult life. F.M.Burnet and F. Fenner highlighted the Owen’s discovery in their monograph “The production of Antibodies”published in 1949. In 1953, P. Medawar and his co-workers showed that tolerance can be experimentallyinduced in fetal mice and in chick embryos. In 1960, Medawar in recognition of the significance of his1953 and 1956 papers was awarded the Nobel Prize in Physiology or Medicine with Burnet for theirdiscovery of acquired immunologic tolerance.
Peter Brian Medawar and the discovery of acquired immunological tolerance
RIBATTI, Domenico
2015-01-01
Abstract
The immunological tolerance was described for the first time with the seminal observations made in1945 by R.D. Owen, demonstrating that cattle dizygotic twins display red cell chimerism in adult life. F.M.Burnet and F. Fenner highlighted the Owen’s discovery in their monograph “The production of Antibodies”published in 1949. In 1953, P. Medawar and his co-workers showed that tolerance can be experimentallyinduced in fetal mice and in chick embryos. In 1960, Medawar in recognition of the significance of his1953 and 1956 papers was awarded the Nobel Prize in Physiology or Medicine with Burnet for theirdiscovery of acquired immunologic tolerance.| File | Dimensione | Formato | |
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