The regioselective lithiation–functionalization of 2-arylazetidines has been explored. The nature of the N-substituent is mainly responsible for a regioselectivity switch. ortho-Lithiation occurred, using hexyllithium as a greener base, in N-alkylazetidines, while abenzylic lithiation has been observed with N-Boc azetidines.
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Titolo: | Regioselective functionalization of 2-arylazetidines: evaluating the ortho-directing ability of the azetidinyl ring and the a-directing ability of the N-substituent |
Autori: | |
Data di pubblicazione: | 2014 |
Rivista: | |
Abstract: | The regioselective lithiation–functionalization of 2-arylazetidines has been explored. The nature of the N-substituent is mainly responsible for a regioselectivity switch. ortho-Lithiation occurred, using hexyllithium as a greener base, in N-alkylazetidines, while abenzylic lithiation has been observed with N-Boc azetidines. |
Handle: | http://hdl.handle.net/11586/136220 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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