Data are reported concerning the anodic behavior of the antihyperuricemia agent allopurinol at a Hg electrode. A method based on flow injection with anodic polarog. detection (FI-APD) was developed for the drug assay in tablets. Polarog. detection is based on the formation of a sparingly sol. Hg compd. A high selectivity, a continuously renewable electrode surface, and no need for deoxygenation of the carrier stream, are the advantages of this approach. The FI-APD method provided an accurate and sensitive drug detn. with a detection limit of 1.8 M and a relative std. deviation of 3.1% at the 28 M level. The sample throughput was 90 samples h-7. The sample treatments involved a sonication-aided tablet dissoln. step in 1 mM NaOH.
Flow injection with anodic polarographic detection for the determination of allopurinol in pharmaceutical formulations.
CATALDI, Tommaso;PALMISANO, Francesco;
1989-01-01
Abstract
Data are reported concerning the anodic behavior of the antihyperuricemia agent allopurinol at a Hg electrode. A method based on flow injection with anodic polarog. detection (FI-APD) was developed for the drug assay in tablets. Polarog. detection is based on the formation of a sparingly sol. Hg compd. A high selectivity, a continuously renewable electrode surface, and no need for deoxygenation of the carrier stream, are the advantages of this approach. The FI-APD method provided an accurate and sensitive drug detn. with a detection limit of 1.8 M and a relative std. deviation of 3.1% at the 28 M level. The sample throughput was 90 samples h-7. The sample treatments involved a sonication-aided tablet dissoln. step in 1 mM NaOH.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
