A quantitative analysis of the frequency of the supercoiled mitochondrial DNA molecules containing the D-loop in rat heart and cerebral hemispheres, at different ages, is presented. Both tissues of aged animals exhibit a remarkable reduction in the content of supercoiled D-loop containing molecules compared to the adults. This alteration could be responsible for the age-dependent reduction of mitochondrial DNA transcription previously observed in rat brain and heart.

Decrease of D-loop frequency in heart and cerebral hemispheres mitochondrial DNA of aged rat / PETRUZZELLA V; FRACASSO F; GADALETA MN; CANTATORE P. - In: MOLECULAR AND CHEMICAL NEUROPATHOLOGY. - ISSN 1044-7393. - 24:2-3(1995), pp. 193-202.

Decrease of D-loop frequency in heart and cerebral hemispheres mitochondrial DNA of aged rat

PETRUZZELLA, Vittoria;CANTATORE, Palmiro
1995

Abstract

A quantitative analysis of the frequency of the supercoiled mitochondrial DNA molecules containing the D-loop in rat heart and cerebral hemispheres, at different ages, is presented. Both tissues of aged animals exhibit a remarkable reduction in the content of supercoiled D-loop containing molecules compared to the adults. This alteration could be responsible for the age-dependent reduction of mitochondrial DNA transcription previously observed in rat brain and heart.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/135640
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