Prospective analysis of 18F-FDG PET/CT predictive value in patients with low rectal cancer treated with neoadjuvant chemoradiotherapy and conservative surgery

Niccoli Asabella, Artor; Altini, C; De Luca, R; Fanelli, Margherita; Rubini, Giuseppe; Caliandro, C; Montemurro, S; Rubini, G.

doi:10.1155/2014/952843

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This study prospectively assessed 18F-FDG PET/CT in predicting the response of locally advanced low rectal cancer (LRC) to neoadjuvant chemoradiation (nCRT). Methods. 56 patients treated with chemoradiation underwent two 18F-FDG PET/CT scans (baseline and 5-6 weeks post-nCRT). 18F-FDGuptake (SUVmax and SUVmean) and differences between baseline (SUV1) and postnCRT (SUV2) scans (ΔSUV and RI%) were evaluated. Results were related to theMandard’s TRG and (y)pTNM. Results. 18F-FDG PET/CT sensitivity, specificity, accuracy, PPV and NPV resulted in 88.6%, 66.7%, 83.92%, 90.7%, and 61.5%. SUV2 resulted in better than SUV1 to predict nCRT response by TRG, with no significant statistical difference between the SUVmax2 and SUVmean2 AUC (0.737 versus 0.736; = 0.928). The same applies to the (y)pTNM (0.798 versus 0.782; = 0.192). In relation to the TRG, RI values had a higher AUC than ΔSUV, with no significant difference between RImax and RImean (0.672 versus 0.695; = 0.292). The same applied to the (y)pTNM (0.742 versus 0.741; = 0.940). In both cases ΔSUV does not appear to be a good predictive tool. Logistic regression confirmed the better predictive role of SUVmax2 for the (y)pTNM (odds ratio = 1.58) and SUVmean2 for the TRG (odds ratio = 1.87). Conclusions. 18F-FDG PET/CT can evaluate response to nCRT in LRC, even if more studies are required to define the most significant parameter for predicting pathologic tumor chan

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Titolo:	Prospective analysis of 18F-FDG PET/CT predictive value in patients with low rectal cancer treated with neoadjuvant chemoradiotherapy and conservative surgery
Autori:	NICCOLI ASABELLA, ARTOR Altini C De Luca R FANELLI, Margherita RUBINI, Giuseppe Caliandro C Montemurro S Rubini G. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	BIOMED RESEARCH INTERNATIONAL
Handle:	http://hdl.handle.net/11586/134641
Appare nelle tipologie:	1.1 Articolo in rivista

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