A number of 3-aryl-5-alkylisoxazoles have been synthesized in high yields by reacting arylnitrile oxides with free enolate ions regioselectively obtained by metallation of various alkyl methyl ketones with LDA in THF at −78°C followed by dehydration. Investigations concerning regioselective side-chain metallation and elaboration of one of them (3-phenyl-5-ethylisoxazole) have also been carried out.
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Titolo: | Regioselective synthesis and side-chain metalation and elaboration of 3-aryl-5-alkylisoxazoles |
Autori: | |
Data di pubblicazione: | 2002 |
Rivista: | |
Abstract: | A number of 3-aryl-5-alkylisoxazoles have been synthesized in high yields by reacting arylnitrile oxides with free enolate ions regioselectively obtained by metallation of various alkyl methyl ketones with LDA in THF at −78°C followed by dehydration. Investigations concerning regioselective side-chain metallation and elaboration of one of them (3-phenyl-5-ethylisoxazole) have also been carried out. |
Handle: | http://hdl.handle.net/11586/133446 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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