In this report, we demonstrate that both TNFR1 and the TNFR2 are expressed on the salivary gland cell line A-253 cell membrane. Furthermore, cell treatment with anti-Ro and anti-La autoantibodies from Sjögren IgG determined TNF-alpha production, clarifying which could be the inducer of the extrinsic pathway of apoptosis in salivary gland cells.
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Titolo: | Anti-Ro and anti-La autoantibodies induce TNF- production by human salivary gland cells: an in vitro study |
Autori: | |
Data di pubblicazione: | 2007 |
Rivista: | |
Abstract: | In this report, we demonstrate that both TNFR1 and the TNFR2 are expressed on the salivary gland cell line A-253 cell membrane. Furthermore, cell treatment with anti-Ro and anti-La autoantibodies from Sjögren IgG determined TNF-alpha production, clarifying which could be the inducer of the extrinsic pathway of apoptosis in salivary gland cells. |
Handle: | http://hdl.handle.net/11586/133260 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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