The stereoselective synthesis of novel α-epoxy-β-amino acids is described by a route that combines the chemistry of oxazolinyloxiranyllithiums with that of nitrones. The intermediate trioxadiazadispiro[2.0.4.3]undecanes 4 have been isolated and converted by hydrolysis into epoxy-5-isoxazolidinones 5 which can be transformed into the α-epoxy-β-amino acids 8 by N−O reduction.

Oxazolinyloxiranyllithium-Mediated Stereoselective Synthesis of alpha-Epoxy-beta-Amino Acids

LUISI, Renzo
Membro del Collaboration Group
;
CAPRIATI, Vito;DEGENNARO, LEONARDO;
2003

Abstract

The stereoselective synthesis of novel α-epoxy-β-amino acids is described by a route that combines the chemistry of oxazolinyloxiranyllithiums with that of nitrones. The intermediate trioxadiazadispiro[2.0.4.3]undecanes 4 have been isolated and converted by hydrolysis into epoxy-5-isoxazolidinones 5 which can be transformed into the α-epoxy-β-amino acids 8 by N−O reduction.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/132380
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