The stereoselective synthesis of novel α-epoxy-β-amino acids is described by a route that combines the chemistry of oxazolinyloxiranyllithiums with that of nitrones. The intermediate trioxadiazadispiro[2.0.4.3]undecanes 4 have been isolated and converted by hydrolysis into epoxy-5-isoxazolidinones 5 which can be transformed into the α-epoxy-β-amino acids 8 by N−O reduction.
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Titolo: | Oxazolinyloxiranyllithium-Mediated Stereoselective Synthesis of alpha-Epoxy-beta-Amino Acids |
Autori: | |
Data di pubblicazione: | 2003 |
Rivista: | |
Abstract: | The stereoselective synthesis of novel α-epoxy-β-amino acids is described by a route that combines the chemistry of oxazolinyloxiranyllithiums with that of nitrones. The intermediate trioxadiazadispiro[2.0.4.3]undecanes 4 have been isolated and converted by hydrolysis into epoxy-5-isoxazolidinones 5 which can be transformed into the α-epoxy-β-amino acids 8 by N−O reduction. |
Handle: | http://hdl.handle.net/11586/132380 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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