Abstract Objective: To assess the performance of different ovarian reserve tests for predicting the total numbers of oocytes retrieved and mature oocytes. Methods: A retrospective study was performed on 71 women undergoing their first IVF/intracytoplasmic sperm injection treatment. Basal ovarian reserve screening was performed on days 2–3 of a spontaneous cycle. Patients were down-regulated with the GnRH agonist, whereas ovarian stimulation was carried out with recombinant FSH, starting from day 2 to 3 of the cycle. The main outcome measures were the numbers of oocytes retrieved and mature oocytes. Results: The total number of oocytes was positively correlated with AFC (p < 0.0001) and E2 levels post-GnRH (p < 0.004), whereas there was an inverse correlation with age (p < 0.0001). The number of mature oocytes also correlated with AFC (p < 0.008) and E2 levels post-GnRH (p < 0.009), and inversely with age (p < 0.0004). Univariate linear regression of square root of number of oocytes (SQNO) shows that acceptable predictors of number oocytes, based on model significance and R2 are AFC (R2 = 0.215), age (R2 = 0.24) and E2 variation (R2 = 0.09). The following model is proposed to predict the number of mature oocytes: ln(MO) = ln(NO)−2.09 + 0.028AGE + 0.03 BMI. Conclusion(s): The number of antral follicles and patient age appear to be good markers of ovarian response in IVF treatments. Additional information is provided by stimulated E2 levels.
Performance of different ovarian reserve markers for predicting the numbers of oocytes retrieved mature oocytes
VICINO, Mario;TREROTOLI, Paolo;SERIO, Gabriella;
2007-01-01
Abstract
Abstract Objective: To assess the performance of different ovarian reserve tests for predicting the total numbers of oocytes retrieved and mature oocytes. Methods: A retrospective study was performed on 71 women undergoing their first IVF/intracytoplasmic sperm injection treatment. Basal ovarian reserve screening was performed on days 2–3 of a spontaneous cycle. Patients were down-regulated with the GnRH agonist, whereas ovarian stimulation was carried out with recombinant FSH, starting from day 2 to 3 of the cycle. The main outcome measures were the numbers of oocytes retrieved and mature oocytes. Results: The total number of oocytes was positively correlated with AFC (p < 0.0001) and E2 levels post-GnRH (p < 0.004), whereas there was an inverse correlation with age (p < 0.0001). The number of mature oocytes also correlated with AFC (p < 0.008) and E2 levels post-GnRH (p < 0.009), and inversely with age (p < 0.0004). Univariate linear regression of square root of number of oocytes (SQNO) shows that acceptable predictors of number oocytes, based on model significance and R2 are AFC (R2 = 0.215), age (R2 = 0.24) and E2 variation (R2 = 0.09). The following model is proposed to predict the number of mature oocytes: ln(MO) = ln(NO)−2.09 + 0.028AGE + 0.03 BMI. Conclusion(s): The number of antral follicles and patient age appear to be good markers of ovarian response in IVF treatments. Additional information is provided by stimulated E2 levels.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
