Stereospecific β-lithiation of β-aryl-substituted oxazolinyloxiranes is described. The trapping reaction of such reactive intermediates with carbonyl compounds gave α,β-epoxy-γ-butyrolactones after deblocking of the oxazoline moiety. This methodology has been also extended to the synthesis of optically active α,β-epoxy-γ-butyrolactones.
Stereospecific beta-Lithiation of Oxazolinyloxiranes: Synthesis of alfa,beta-Epoxy-gamma-butyrolactones
CAPRIATI, Vito;DEGENNARO, LEONARDO;LUISI, Renzo
2002-01-01
Abstract
Stereospecific β-lithiation of β-aryl-substituted oxazolinyloxiranes is described. The trapping reaction of such reactive intermediates with carbonyl compounds gave α,β-epoxy-γ-butyrolactones after deblocking of the oxazoline moiety. This methodology has been also extended to the synthesis of optically active α,β-epoxy-γ-butyrolactones.File in questo prodotto:
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