The ortho lithiation-trapping sequence of phenylaziridines is described. This methodology, which counts on the ability of the aziridino group to act as a directed metalation group (DMG), provides an easy access to functionalized arylaziridines as well as to phthalans and phthalides. The importance of the aziridine N-substituent in this DoM reaction is stressed as well.

Direct Ortho Lithiation of N-Alkylphenylaziridines

CAPRIATI, Vito;LUISI, Renzo;
2005-01-01

Abstract

The ortho lithiation-trapping sequence of phenylaziridines is described. This methodology, which counts on the ability of the aziridino group to act as a directed metalation group (DMG), provides an easy access to functionalized arylaziridines as well as to phthalans and phthalides. The importance of the aziridine N-substituent in this DoM reaction is stressed as well.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/130235
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