In the mare, endogenous opioid peptides are involved in the suppression of gonadotropin secretion in seasonal anestrus and we found a high incidence of apoptotic follicles in anestrous mares. A role of endogenous opioid peptides in promoting cell death has been reported (Yin et al., Nature 1999; 397:218) and neuronal apoptisis is associated with abnormal intracellular calcium levels (Mason et al., J Neurochem 1999;72:1448-1456). This study examines the effects of Naloxone and calcium administration on follicular development and apoptosis in anestrus mares.
Follicular growth in anestrus mares treated with naloxone and calcium: role of opioids in the control of apoptosis in granulosa cells
SCIORSCI, Raffaele Luigi;ALBRIZIO, MARIA;CINONE, Mario;AIUDI, GIULIO GUIDO;LACALANDRA G. M. , RICCI L.;
2000-01-01
Abstract
In the mare, endogenous opioid peptides are involved in the suppression of gonadotropin secretion in seasonal anestrus and we found a high incidence of apoptotic follicles in anestrous mares. A role of endogenous opioid peptides in promoting cell death has been reported (Yin et al., Nature 1999; 397:218) and neuronal apoptisis is associated with abnormal intracellular calcium levels (Mason et al., J Neurochem 1999;72:1448-1456). This study examines the effects of Naloxone and calcium administration on follicular development and apoptosis in anestrus mares.File in questo prodotto:
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