Paraneoplastic focal segmental glomerulosclerosis in sarcomatoid renal cell cancer.

Case Report. A 68-year-old white man was admitted to the Department of Biomedical Science and Clinical Oncology of the University of Bari for both weakness and anasarca. He suffered from mild hypertension and was overweight. Blood tests showed impaired renal function parameters with increased serum creatinine (3.1 mg/dL) and urea (95 mg/dL), defective creatinine clearance (28 mL/min), and reduced plasma proteins (4.8 g/dL). Urinalysis revealed a protein content of more than 400 mg/dL, with a daily proteinuria of 33 g. The clinical presentation was thus suggestive of severe nephrotic syndrome (NS).