Electrolyte gated organic field-effect transistor sensors based on supported biotinylated phospholipid bilayer

There is an increasing interest in low cost, timesaving, yet reliable, point-of-care assays. Direct electronic, label-free transduction of bio-recognition events represents a compelling alternative offering miniaturization, easy data handling and processing. Low costs and versatility can be provided if organic electronic devices such as organic fi eld-effect transistors (OFETs) are used as transducers. [ 1 , 2 ] At the beginning, OFET sensors were mostly involved the detection of volatile chemical analytes, [ 3 , 4 ] while organic electronics allowed fabrication of sensing circuits on fl exible substrates. [ 5 , 6 ] However, bare OFET-sensor responses are based on weak interactions that are non-specifi c in nature. Specifi city can be achieved by endowing the OFET with receptor molecules capable of selectively interacting with given analytes.