Formation of bile and generation of bile flow are driven by the active secretion of bile salts (BS), lipids and electrolytes into the canalicular and bile duct lumens followed by the osmotic movement of water. Although the transporting proteins involved in solute secretion have been cloned and their coordinated interplay defined both in health and disease, boosted by the discovery of the aquaporin water channels, only recently has considerable attention been addressed to the mechanism by which water, the major component of bile (> 95%), moves across the hepatobiliary epithelia. This review summarizes the novel acquisitions in liver membrane water transport and functional participation of aquaporin water channels in multiple aspects of hepatobiliary fluid balance. Emerging evidences suggesting involvement of aquaporins in the metabolic homeostasis of the hepatobiliary tract are also discussed.
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|Titolo:||Water transport into bile and role in bile formation|
|Data di pubblicazione:||2005|
|Citazione:||Water transport into bile and role in bile formation / CALAMITA G; FERRI D.; GENA P.; LIQUORI G.E.; MARINELLI R.A.; PORTINCASA P.; SVELTO M.. - In: CURRENT DRUG TARGETS- IMMUNE, ENDOCRINE & METABOLIC DISORDERS. - ISSN 1568-0088. - 5:2(2005), pp. 137-152.|
|Appare nelle tipologie:||1.1 Articolo in rivista|