In humans, monocytes and macrophages (MO) play a central role in immune regulation, tissue maintenance and pathogen control. In lower vertebrates, a few studies have been conducted on MO like cells. In acute monocytic leukemia monocytic cells, as immature cells restrained in one of the phases of their ontogenesis, would offer the opportunity to rebuild an archaic condition helpful to understand the phylogenesis. Therefore, aim of this work was to characterize in the Rainbow trout (Salmo Gairdneri Richardson) MO and compare them with acute leukemia monocytic cells. In the trout, MO' s morphology is similar to that of mammals. In particular, MO possess an irregular embryoshaped nucleus occupying 2/3 of the cell, while the peripheral cytoplasmic profile is irregular with extroflexed plasmalemma and pseudopods. A morphological transition towards MO is featured by a wavy hyaline classical membrane and an irregular and extroflexed surface.
In humans, monocytes and macrophages (MO) play a central role in immune regulation, tissue maintenance and pathogen control. In lower vertebrates, a few studies have been conducted on MO like cells. In acute monocytic leukemia monocytic cells, as immature cells restrained in one of the phases of their ontogenesis, would offer the opportunity to rebuild an archaic condition helpful to understand the phylogenesis. Therefore, aim of this work was to characterize in the Rainbow trout (Salmo Gairdneri Richardson) MO and compare them with acute leukemia monocytic cells.In the trout, MO' s morphology is similar to that of mammals. In particular, MO possess an irregular embryoshaped nucleus occupying 2/3 of the cell, while the peripheral cytoplasmic profile is irregular with extroflexed plasmalemma and pseudopods.A morphological transition towards MO is featured by a wavy hyaline classical membrane and an irregular and extroflexed surface.
A phylogenetic comparison between acute monocytic leukemia cells and monocytes-macrophages in lower vertebrates
PASSANTINO, Letizia;PASSANTINO, Giuseppe;
2003-01-01
Abstract
In humans, monocytes and macrophages (MO) play a central role in immune regulation, tissue maintenance and pathogen control. In lower vertebrates, a few studies have been conducted on MO like cells. In acute monocytic leukemia monocytic cells, as immature cells restrained in one of the phases of their ontogenesis, would offer the opportunity to rebuild an archaic condition helpful to understand the phylogenesis. Therefore, aim of this work was to characterize in the Rainbow trout (Salmo Gairdneri Richardson) MO and compare them with acute leukemia monocytic cells.In the trout, MO' s morphology is similar to that of mammals. In particular, MO possess an irregular embryoshaped nucleus occupying 2/3 of the cell, while the peripheral cytoplasmic profile is irregular with extroflexed plasmalemma and pseudopods.A morphological transition towards MO is featured by a wavy hyaline classical membrane and an irregular and extroflexed surface.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
