The preparation of N-substituted oxazolinylaziridines and their deprotonation to afford the corresponding aziridinyllithiums is described. The chemical and configurational stability of the lithiated species depends on the N-substituent on the aziridine ring. The trapping with carbonyl compounds of (R*,S*) configurated oxazolinylaziridines is an interesting route for the preparation of functionalised alpha,beta-aziridino-gamma-lactones.
Synthesis and Lithiation of Oxazolinylaziridines: the N-substituent Effect
LUISI, Renzo;CAPRIATI, Vito;
2005-01-01
Abstract
The preparation of N-substituted oxazolinylaziridines and their deprotonation to afford the corresponding aziridinyllithiums is described. The chemical and configurational stability of the lithiated species depends on the N-substituent on the aziridine ring. The trapping with carbonyl compounds of (R*,S*) configurated oxazolinylaziridines is an interesting route for the preparation of functionalised alpha,beta-aziridino-gamma-lactones.File in questo prodotto:
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