A stereoselective synthesis of tetrasubstituted 2,3-dihydrofurans was carried out in n-butylpyridinium tetrafluoroborate ([bpy+][BF4 -]) as solvent. The reaction proceeds smoothly in one step starting from simple materials such as aldehydes and â-ketosulfides of benzothiazole. A comparison between several ionic liquids (ILs) is presented, and the role of the benzothiazolyl moiety is discussed. Workup proved to be very easy and recycling of IL possible.
Stereoselective synthesis of tetrasubstituted 2,3-dihydrofurans by one-step cyclization of beta-ketosulfides of benzothiazole and aldehydes in ionic liquids
NACCI, Angelo
;SCHINGARO, Emanuela;D'ACCOLTI, Lucia;MONOPOLI A.
2003-01-01
Abstract
A stereoselective synthesis of tetrasubstituted 2,3-dihydrofurans was carried out in n-butylpyridinium tetrafluoroborate ([bpy+][BF4 -]) as solvent. The reaction proceeds smoothly in one step starting from simple materials such as aldehydes and â-ketosulfides of benzothiazole. A comparison between several ionic liquids (ILs) is presented, and the role of the benzothiazolyl moiety is discussed. Workup proved to be very easy and recycling of IL possible.File in questo prodotto:
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