The reaction of ortho-lithiated aryloxiranes with various enaminones straightforwardly affords new functionalized isochromanes as mixtures of two epimeric stereoisomers in reasonable to very good yields (50–90%). The two diastereomers, which show a high structural variability, can be easily separated by column chromatography.

Preparation of Polysubstituted Isochromanes by Addition of ortho-Lithiated Aryloxiranes to Enaminones

Salomone A;PERNA, FILIPPO;CAPRIATI, Vito
2013

Abstract

The reaction of ortho-lithiated aryloxiranes with various enaminones straightforwardly affords new functionalized isochromanes as mixtures of two epimeric stereoisomers in reasonable to very good yields (50–90%). The two diastereomers, which show a high structural variability, can be easily separated by column chromatography.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/115529
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