The reaction of ortho-lithiated aryloxiranes with various enaminones straightforwardly affords new functionalized isochromanes as mixtures of two epimeric stereoisomers in reasonable to very good yields (50–90%). The two diastereomers, which show a high structural variability, can be easily separated by column chromatography.
Preparation of polysubstituted isochromanes by addition of ortho-lithiated aryloxiranes to enaminones
Salomone, Antonio;Perna, Filippo Maria;Falcicchio, Aurelia;Florio, Saverio
;Capriati, Vito
2013-01-01
Abstract
The reaction of ortho-lithiated aryloxiranes with various enaminones straightforwardly affords new functionalized isochromanes as mixtures of two epimeric stereoisomers in reasonable to very good yields (50–90%). The two diastereomers, which show a high structural variability, can be easily separated by column chromatography.File in questo prodotto:
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