By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl-or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.

Synthesis of functionalized arylaziridines as potential antimicrobial agents

Muraglia M.;ROSATO, Antonio;CORBO, Filomena Faustina Rina;FRANCHINI, Carlo;DEGENNARO, LEONARDO;LUISI, Renzo
2014-01-01

Abstract

By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl-or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/115236
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