In conclusion, the number and variety of ETV6 translocations not resulting in a fusion protein, together with loss of ETV6 by deletion and heterozygous or homozygous mutations, makes a mutually supportive and compelling case for loss and haploinsufficiency of ETV6 as a leukemogenic step in AML-M0.
ETV6 mutations and loss in AML-M0
STORLAZZI, CLELIA TIZIANA;ZAGARIA, ANTONELLA;
2008
Abstract
In conclusion, the number and variety of ETV6 translocations not resulting in a fusion protein, together with loss of ETV6 by deletion and heterozygous or homozygous mutations, makes a mutually supportive and compelling case for loss and haploinsufficiency of ETV6 as a leukemogenic step in AML-M0.File in questo prodotto:
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