Apraclonidine hydrochloride is a potent and relatively selective alpha2-adrenergic receptor agonist. The alpha2-adrenoceptor is widely expressed in the eye, located in the anterior segment for example in the cornea, trabecular meshwork, iris, ciliary body epithelium and ciliary muscle and in the posterior segment in structures such as the retina, retinal pigment epithelium and choroid. Apraclonidine is useful in the diagnosis of Horner Syndrome. It is also used to prevent intraocular pressure spikes after anterior segment laser surgery or following cataract surgery. It can also be used as a temporary adjunctive drug in patients with open-angle glaucoma on maximal therapy before laser trabeculoplasty or surgery, and as a treatment for ptosis secondary to injections of botulinum toxin on the upper third of the face.
Apraclonidine hydrochloride: pharmacology and clinical use
LOGRANO, Marcello Diego
2008-01-01
Abstract
Apraclonidine hydrochloride is a potent and relatively selective alpha2-adrenergic receptor agonist. The alpha2-adrenoceptor is widely expressed in the eye, located in the anterior segment for example in the cornea, trabecular meshwork, iris, ciliary body epithelium and ciliary muscle and in the posterior segment in structures such as the retina, retinal pigment epithelium and choroid. Apraclonidine is useful in the diagnosis of Horner Syndrome. It is also used to prevent intraocular pressure spikes after anterior segment laser surgery or following cataract surgery. It can also be used as a temporary adjunctive drug in patients with open-angle glaucoma on maximal therapy before laser trabeculoplasty or surgery, and as a treatment for ptosis secondary to injections of botulinum toxin on the upper third of the face.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
