[Fetal glucose regulation: glycosylated hemoglobin in cord blood]. FT Studio della glicoregolazione fetale: l'emoglobina glicosilata funicolare.

Glycosylated haemoglobins were assayed at delivery in 64 pregnant women (48 normals and 16 diabetics) in maternal and cord blood with the colorimetric method of Fluckiger and Winter-halter. A good correlation was observed between maternal and funicular glycosylated Hb (r = 0.67, p less than 0.001) in normal subjects; there wasn't any significant correlation in diabetic pregnant; (r = 0.29). Maternal glycosylated haemoglobins were compared to Schlichkrull's M of glycemic cycles in diabetic pregnant all these subjects showed a good glycemic regulation. Colorimetric technique can separate glycosylated haemoglobins from Hb F, and so allows their detection in cord blood. Glycosylated haemoglobin's assay in cord blood at delivery is an index of fetal glycoregulation in the last trimester of pregnancy and it represents a parameter of fetal pancreatic insulin incretion during intrauterine growth.