General population is exposed to benzene and polycyclic aromatic hydrocarbons (PAH). The aim of the study was to evaluate the relationships between personal environmental exposures to the above chemicals and several biomarkers. The paper reports the environmental and biological monitoring data collected from 15 people living in the rural area of Alberobello (Bari, Italy) and 18 people living in Taranto (Italy), near an important steel plant. Airborne PAH and benzene personal exposure levels were determined as well as urinary concentrations of benzene, trans,trans-muconic acid and 1- hydroxypyrene. PAH-DNA adducts levels in peripheral blood lymphocytes were also determined. The influence of genetic polymorphism of cytochrome P450 1A1 (CYP1A1), glutathione transferases μ, θ (GSTM1, GSTT1) and DNA repair gene (XPD) on biomarkers levels was investigated.

Valutazione dell’esposizione ambientale ad IPA e benzene in popolazioni residenti in prossimità di un impianto siderurgico ed in un’area rurale

CARRUS A;SCHIAVULLI, Nunzia Anna;VIMERCATI, LUIGI;
2006

Abstract

General population is exposed to benzene and polycyclic aromatic hydrocarbons (PAH). The aim of the study was to evaluate the relationships between personal environmental exposures to the above chemicals and several biomarkers. The paper reports the environmental and biological monitoring data collected from 15 people living in the rural area of Alberobello (Bari, Italy) and 18 people living in Taranto (Italy), near an important steel plant. Airborne PAH and benzene personal exposure levels were determined as well as urinary concentrations of benzene, trans,trans-muconic acid and 1- hydroxypyrene. PAH-DNA adducts levels in peripheral blood lymphocytes were also determined. The influence of genetic polymorphism of cytochrome P450 1A1 (CYP1A1), glutathione transferases μ, θ (GSTM1, GSTT1) and DNA repair gene (XPD) on biomarkers levels was investigated.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/100024
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