DELRE, PIETRO
DELRE, PIETRO
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach
2023-01-01 Abatematteo, Francesca Serena; Delre, Pietro; Mercurio, Ivan; Rezelj, Veronica V; Siliqi, Dritan; Beaucourt, Stephanie; Lattanzi, Gianluca; Colabufo, Nicola Antonio; Leopoldo, Marcello; Saviano, Michele; Vignuzzi, Marco; Mangiatordi, Giuseppe Felice; Abate, Carmen
ALPACA: A machine Learning Platform for Affinity and selectivity profiling of CAnnabinoids receptors modulators
2023-01-01 Delre, Pietro; Contino, Marialessandra; Alberga, Domenico; Saviano, Michele; Corriero, Nicola; Mangiatordi, Giuseppe Felice
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis
2023-01-01 Lomuscio, Maria Cristina; Abate, Carmen; Alberga, Domenico; Laghezza, Antonio; Corriero, Nicola; Colabufo, Nicola Antonio; Saviano, Michele; Delre, Pietro; Mangiatordi, Giuseppe Felice
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors
2023-01-01 Rullo, Mariagrazia; La Spada, Gabriella; Miniero, Daniela Valeria; Gottinger, Andrea; Catto, Marco; Delre, Pietro; Mastromarino, Margherita; Latronico, Tiziana; Marchese, Sara; Mangiatordi, Giuseppe Felice; Binda, Claudia; Linusson, Anna; Liuzzi, Grazia Maria; Pisani, Leonardo
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration
2020-01-01 Mangiatordi, Giuseppe Felice; Intranuovo, Francesca; Delre, Pietro; Abatematteo, Francesca Serena; Abate, Carmen; Niso, Mauro; Creanza, Teresa Maria; Ancona, Nicola; Stefanachi, Angela; Contino, Marialessandra
Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self-Assembled Monolayers
2023-01-01 Sarcina, L.; Delre, P.; Graziano, G.; Stefanachi, A.; Blasi, D.; Picca, R. A.; Di Franco, C.; Leonetti, F.; Scamarcio, G.; Bollella, P.; Mangiatordi, G. F.; Macchia, E.; Torsi, L.
DeLA-Drug: A Deep Learning Algorithm for Automated Design of Druglike Analogues
2022-01-01 Creanza, Teresa Maria; Lamanna, Giuseppe; Delre, Pietro; Contino, Marialessandra; Corriero, Nicola; Saviano, Michele; Mangiatordi, Giuseppe Felice; Ancona, Nicola
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation
2024-01-01 Alberga, D.; Lamanna, G.; Graziano, G.; Delre, P.; Lomuscio, M. C.; Corriero, N.; Ligresti, A.; Siliqi, D.; Saviano, M.; Contino, M.; Stefanachi, A.; Mangiatordi, G. F.
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques
2023-01-01 Abatematteo, F. S.; Majellaro, M.; Montsch, B.; Prieto-Diaz, R.; Niso, M.; Contino, M.; Stefanachi, A.; Riganti, C.; Mangiatordi, G. F.; Delre, P.; Heffeter, P.; Sotelo, E.; Abate, C.
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase
2023-01-01 Intranuovo, Francesca; Brunetti, Leonardo; Delre, Pietro; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Laghezza, Antonio; Niso, Mauro; Leonetti, Francesco; Loiodice, Fulvio; Ligresti, Alessia; Kostrzewa, Magdalena; Brea, Jose; Isabel Loza, Maria; Sotelo, Eddy; Saviano, Michele; Colabufo, Nicola Antonio; Riganti, Chiara; Abate, Carmen; Contino, Marialessandra
Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels
2023-01-01 Farinato, A.; Cavalluzzi, M. M.; Altamura, C.; Campanale, C.; Laghetti, P.; Saltarella, I.; Delre, P.; Barbault, A.; Tarantino, N.; Milani, G.; Rotondo, N. P.; Di Cesare Mannelli, L.; Ghelardini, C.; Pierno, S.; Mangiatordi, G. F.; Lentini, G.; Desaphy, J. -F.
Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective
2023-01-01 Mangiatordi, Giuseppe Felice; Cavalluzzi, MARIA MADDALENA; Delre, Pietro; Lamanna, Giuseppe; Cristina Lumuscio, Maria; Saviano, Michele; Majoral, Jean-Pierre; Mignani, SERGE MARIE; Duranti, Andrea; Lentini, Giovanni
Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics
2019-01-01 Delre, P.; Alberga, D.; Gijsbers, A.; Sanchez-Puig, N.; Nicolotti, O.; Saviano, M.; Siliqi, D.; Mangiatordi, G. F.
hERG stereoselective modulation by mexiletine‐derived ureas: Molecular docking study, synthesis, and biological evaluation
2023-01-01 Milani, Gualtiero; Budriesi, Roberta; Tavazzani, Elisa; Cavalluzzi, MARIA MADDALENA; Beatrice Mattioli, Laura; Miniero, DANIELA VALERIA; Delre, Pietro; Belviso, BENNY DANILO; Denegri, Marco; Cuocci, Corrado; Rotondo, NATALIE PAOLA; DE PALMA, Annalisa; Gualdani, Roberta; Caliandro, Rocco; Mangiatordi, Giuseppe Felice; Kumawat, Amit; Camilloni, Carlo; Priori, Silvia; Lentini, Giovanni
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R)
2023-01-01 Graziano, G.; Delre, P.; Carofiglio, F.; Brea, J.; Ligresti, A.; Kostrzewa, M.; Riganti, C.; Gioe-Gallo, C.; Majellaro, M.; Nicolotti, O.; Colabufo, N. A.; Abate, C.; Loza, M. I.; Sotelo, E.; Mangiatordi, G. F.; Contino, M.; Stefanachi, A.; Leonetti, F.
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R)
2024-01-01 Intranuovo, Francesca; Majellaro, Maria; Mastropasqua, Francesco; Delre, Pietro; Abatematteo, FRANCESCA SERENA; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Brea, José; Isabel Loza, Maria; Riganti, Chiara; Ligresti, Alessia; Kumar, Poulami; Esposito, Daniela; Cristino, Luigia; Nicois, Alessandro; Gonzalez, Lucia; Perrone, MARIA GRAZIA; Colabufo, Nicola Antonio; Sotelo, Eddy; Abate, Carmen; Contino, Marialessandra
Radiosynthesis and characterization of [18F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism
2021-01-01 Lee, S. H.; Denora, N.; Laquintana, V.; Mangiatordi, G. F.; Lopedota, A.; Lopalco, A.; Cutrignelli, A.; Franco, M.; Delre, P.; Song, I. H.; Kim, H. W.; Kim, S. B.; Park, H. S.; Kim, K.; Lee, S. -Y.; Youn, H.; Lee, B. C.; Kim, S. E.
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization
2024-01-01 La Spada, Gabriella; Miniero, Daniela Valeria; Rullo, Mariagrazia; Cipolloni, Marco; Delre, Pietro; Colliva, Carolina; Colella, Marco; Leonetti, Francesco; Liuzzi, Grazia Maria; Mangiatordi, Giuseppe Felice; Giacchè, Nicola; Pisani, Leonardo
Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study
2021-01-01 Creanza, Teresa Maria; Delre, Pietro; Ancona, Nicola; Lentini, Giovanni; Saviano, Michele; Mangiatordi, Giuseppe Felice
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach | 1-gen-2023 | Abatematteo, Francesca Serena; Delre, Pietro; Mercurio, Ivan; Rezelj, Veronica V; Siliqi, Dritan; Beaucourt, Stephanie; Lattanzi, Gianluca; Colabufo, Nicola Antonio; Leopoldo, Marcello; Saviano, Michele; Vignuzzi, Marco; Mangiatordi, Giuseppe Felice; Abate, Carmen | |
| ALPACA: A machine Learning Platform for Affinity and selectivity profiling of CAnnabinoids receptors modulators | 1-gen-2023 | Delre, Pietro; Contino, Marialessandra; Alberga, Domenico; Saviano, Michele; Corriero, Nicola; Mangiatordi, Giuseppe Felice | |
| AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis | 1-gen-2023 | Lomuscio, Maria Cristina; Abate, Carmen; Alberga, Domenico; Laghezza, Antonio; Corriero, Nicola; Colabufo, Nicola Antonio; Saviano, Michele; Delre, Pietro; Mangiatordi, Giuseppe Felice | |
| Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors | 1-gen-2023 | Rullo, Mariagrazia; La Spada, Gabriella; Miniero, Daniela Valeria; Gottinger, Andrea; Catto, Marco; Delre, Pietro; Mastromarino, Margherita; Latronico, Tiziana; Marchese, Sara; Mangiatordi, Giuseppe Felice; Binda, Claudia; Linusson, Anna; Liuzzi, Grazia Maria; Pisani, Leonardo | |
| Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration | 1-gen-2020 | Mangiatordi, Giuseppe Felice; Intranuovo, Francesca; Delre, Pietro; Abatematteo, Francesca Serena; Abate, Carmen; Niso, Mauro; Creanza, Teresa Maria; Ancona, Nicola; Stefanachi, Angela; Contino, Marialessandra | |
| Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self-Assembled Monolayers | 1-gen-2023 | Sarcina, L.; Delre, P.; Graziano, G.; Stefanachi, A.; Blasi, D.; Picca, R. A.; Di Franco, C.; Leonetti, F.; Scamarcio, G.; Bollella, P.; Mangiatordi, G. F.; Macchia, E.; Torsi, L. | |
| DeLA-Drug: A Deep Learning Algorithm for Automated Design of Druglike Analogues | 1-gen-2022 | Creanza, Teresa Maria; Lamanna, Giuseppe; Delre, Pietro; Contino, Marialessandra; Corriero, Nicola; Saviano, Michele; Mangiatordi, Giuseppe Felice; Ancona, Nicola | |
| DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation | 1-gen-2024 | Alberga, D.; Lamanna, G.; Graziano, G.; Delre, P.; Lomuscio, M. C.; Corriero, N.; Ligresti, A.; Siliqi, D.; Saviano, M.; Contino, M.; Stefanachi, A.; Mangiatordi, G. F. | |
| Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques | 1-gen-2023 | Abatematteo, F. S.; Majellaro, M.; Montsch, B.; Prieto-Diaz, R.; Niso, M.; Contino, M.; Stefanachi, A.; Riganti, C.; Mangiatordi, G. F.; Delre, P.; Heffeter, P.; Sotelo, E.; Abate, C. | |
| Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase | 1-gen-2023 | Intranuovo, Francesca; Brunetti, Leonardo; Delre, Pietro; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Laghezza, Antonio; Niso, Mauro; Leonetti, Francesco; Loiodice, Fulvio; Ligresti, Alessia; Kostrzewa, Magdalena; Brea, Jose; Isabel Loza, Maria; Sotelo, Eddy; Saviano, Michele; Colabufo, Nicola Antonio; Riganti, Chiara; Abate, Carmen; Contino, Marialessandra | |
| Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels | 1-gen-2023 | Farinato, A.; Cavalluzzi, M. M.; Altamura, C.; Campanale, C.; Laghetti, P.; Saltarella, I.; Delre, P.; Barbault, A.; Tarantino, N.; Milani, G.; Rotondo, N. P.; Di Cesare Mannelli, L.; Ghelardini, C.; Pierno, S.; Mangiatordi, G. F.; Lentini, G.; Desaphy, J. -F. | |
| Endocannabinoid Degradation Enzyme Inhibitors as Potential Antipsychotics: A Medicinal Chemistry Perspective | 1-gen-2023 | Mangiatordi, Giuseppe Felice; Cavalluzzi, MARIA MADDALENA; Delre, Pietro; Lamanna, Giuseppe; Cristina Lumuscio, Maria; Saviano, Michele; Majoral, Jean-Pierre; Mignani, SERGE MARIE; Duranti, Andrea; Lentini, Giovanni | |
| Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics | 1-gen-2019 | Delre, P.; Alberga, D.; Gijsbers, A.; Sanchez-Puig, N.; Nicolotti, O.; Saviano, M.; Siliqi, D.; Mangiatordi, G. F. | |
| hERG stereoselective modulation by mexiletine‐derived ureas: Molecular docking study, synthesis, and biological evaluation | 1-gen-2023 | Milani, Gualtiero; Budriesi, Roberta; Tavazzani, Elisa; Cavalluzzi, MARIA MADDALENA; Beatrice Mattioli, Laura; Miniero, DANIELA VALERIA; Delre, Pietro; Belviso, BENNY DANILO; Denegri, Marco; Cuocci, Corrado; Rotondo, NATALIE PAOLA; DE PALMA, Annalisa; Gualdani, Roberta; Caliandro, Rocco; Mangiatordi, Giuseppe Felice; Kumawat, Amit; Camilloni, Carlo; Priori, Silvia; Lentini, Giovanni | |
| N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) | 1-gen-2023 | Graziano, G.; Delre, P.; Carofiglio, F.; Brea, J.; Ligresti, A.; Kostrzewa, M.; Riganti, C.; Gioe-Gallo, C.; Majellaro, M.; Nicolotti, O.; Colabufo, N. A.; Abate, C.; Loza, M. I.; Sotelo, E.; Mangiatordi, G. F.; Contino, M.; Stefanachi, A.; Leonetti, F. | |
| N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) | 1-gen-2024 | Intranuovo, Francesca; Majellaro, Maria; Mastropasqua, Francesco; Delre, Pietro; Abatematteo, FRANCESCA SERENA; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Brea, José; Isabel Loza, Maria; Riganti, Chiara; Ligresti, Alessia; Kumar, Poulami; Esposito, Daniela; Cristino, Luigia; Nicois, Alessandro; Gonzalez, Lucia; Perrone, MARIA GRAZIA; Colabufo, Nicola Antonio; Sotelo, Eddy; Abate, Carmen; Contino, Marialessandra | |
| Radiosynthesis and characterization of [18F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism | 1-gen-2021 | Lee, S. H.; Denora, N.; Laquintana, V.; Mangiatordi, G. F.; Lopedota, A.; Lopalco, A.; Cutrignelli, A.; Franco, M.; Delre, P.; Song, I. H.; Kim, H. W.; Kim, S. B.; Park, H. S.; Kim, K.; Lee, S. -Y.; Youn, H.; Lee, B. C.; Kim, S. E. | |
| Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization | 1-gen-2024 | La Spada, Gabriella; Miniero, Daniela Valeria; Rullo, Mariagrazia; Cipolloni, Marco; Delre, Pietro; Colliva, Carolina; Colella, Marco; Leonetti, Francesco; Liuzzi, Grazia Maria; Mangiatordi, Giuseppe Felice; Giacchè, Nicola; Pisani, Leonardo | |
| Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study | 1-gen-2021 | Creanza, Teresa Maria; Delre, Pietro; Ancona, Nicola; Lentini, Giovanni; Saviano, Michele; Mangiatordi, Giuseppe Felice |