BRUNETTI, LEONARDO
BRUNETTI, LEONARDO
DIPARTIMENTO DI FARMACIA-SCIENZE DEL FARMACO
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone
2021-01-01 Laghezza, A.; Piemontese, L.; Brunetti, L.; Caradonna, A.; Agamennone, M.; Loiodice, F.; Tortorella, P.
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease
2022-01-01 Czarnota-Łydka, Kinga; Satała, Grzegorz; Brunetti, Leonardo; Laghezza, Antonio; Piemontese, Luca; DE CANDIA, Modesto; Purgatorio, Rosa; Gumułka, Magdalena; Kucwaj-Brysz, Katarzyna; Carrieri, Antonio; Handzlik, Jadwiga
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties
2024-01-01 Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Montanari, Roberta; Capelli, Davide; Wackerlig, Judith; Simic, Stefan; Falbo, Emanuele; Pecora, Lucia; Leuci, Rosalba; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Singh, Ravi Pratap; Tambe, Suhas; Sudeep, C. A.; Pattnaik, Ashok Kumar; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity
2022-01-01 Sblano, S.; Cerchia, C.; Laghezza, A.; Piemontese, L.; Brunetti, L.; Leuci, R.; Gilardi, F.; Thomas, A.; Genovese, M.; Santi, A.; Tortorella, P.; Paoli, P.; Lavecchia, A.; Loiodice, F.
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION
2023-01-01 Cerchia, C.; Laghezza, A.; Genovese, M.; Leuci, R.; Pranzini, E.; Santi, A.; Brunetti, L.; Piemontese, L.; Tortorella, P.; Biswas, A.; Singh, R. P.; Tambe, S.; Ca, S.; Pattnaik, A. K.; Jayaprakash, V.; Paoli, P.; Loiodice, F.; Lavecchia, A.
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition
2023-01-01 Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Leuci, Rosalba; Pranzini, Erica; Santi, Alice; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Pratap Singh, Ravi; Tambe, Suhas; Ca, Sudeep; Kumar Pattnaik, Ashok; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE)
2022-01-01 Leuci, R.; Brunetti, L.; Laghezza, A.; Piemontese, L.; Carrieri, A.; Pisani, L.; Tortorella, P.; Catto, M.; Loiodice, F.
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders
2020-01-01 Leuci, Rosalba; Brunetti, Leonardo; Laghezza, Antonio; Tortorella, Paolo; Loiodice, Fulvio; Piemontese, Luca
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey
2024-01-01 Brunetti, Leonardo; Francavilla, Fabio; Leopoldo, Marcello; Lacivita, Enza
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors
2020-01-01 Brunetti, Leonardo; Carrieri, Antonio; Piemontese, Luca; Tortorella, Paolo; Loiodice, Fulvio; Laghezza, Antonio
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy
2020-01-01 Laghezza, A.; Piemontese, L.; Brunetti, L.; Caradonna, A.; Agamennone, M.; Di Pizio, A.; Pochetti, G.; Montanari, R.; Capelli, D.; Tauro, M.; Loiodice, F.; Tortorella, P.
Can foods influence the onset and progress of neurodegenerative diseases?
2022-01-01 Piemontese, Luca; Brunetti, Leonardo; Leuci, Rosalba
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases
2024-01-01 Carrieri, Antonio; Barbarossa, Alexia; de Candia, Modesto; Samarelli, Francesco; Damiano Altomare, Cosimo; Czarnota-Łydka, Kinga; Sudoł-Tałaj, Sylwia; Latacz, Gniewomir; Handzlik, Jadwiga; Brunetti, Leonardo; Piemontese, Luca; Limongelli, Francesco; Lentini, Giovanni; Carocci, Alessia
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease
2020-01-01 Brunetti, Leonardo; Laghezza, Antonio; Loiodice, Fulvio; Tortorella, Paolo; Piemontese, Luca
Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2‐Hydroxyphenylbenzimidazole-based Scaffolds en Route to Donepezil‐Like Compounds
2020-01-01 Piemontese, L.; Sergio, R.; Rinaldo, F.; Brunetti, L.; Perna, F. M.; Amelia Santos, M.; Capriati, V.
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents
2021-01-01 Poliseno, Viviana; Chaves, Sílvia; Brunetti, Leonardo; Loiodice, Fulvio; Carrieri, Antonio; Laghezza, Antonio; Tortorella, Paolo; Magalhães, João D.; Cardoso, Sandra M.; Santos, M. Amélia; Piemontese, Luca
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase
2023-01-01 Intranuovo, Francesca; Brunetti, Leonardo; Delre, Pietro; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Laghezza, Antonio; Niso, Mauro; Leonetti, Francesco; Loiodice, Fulvio; Ligresti, Alessia; Kostrzewa, Magdalena; Brea, Jose; Isabel Loza, Maria; Sotelo, Eddy; Saviano, Michele; Colabufo, Nicola Antonio; Riganti, Chiara; Abate, Carmen; Contino, Marialessandra
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect
2022-01-01 Abatematteo, F. S.; Mosier, P. D.; Niso, M.; Brunetti, L.; Berardi, F.; Loiodice, F.; Contino, M.; Delprat, B.; Maurice, T.; Laghezza, A.; Abate, C.
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY
2021-01-01 Laghezza, Antonio; Abatematteo, Francesca S.; Mosier, Philip D.; Niso, Mauro; Brunetti, Leonardo; Berardi, Francesco; Loiodice, Fulvio; Contino, Marialessandra; Delprat, Benjamin; Maurice, Tangui; Abate, Carmen
Discovery of a dual PPARα/γ partial agonist displaying antisteatotic and antidiabetic properties: in silico studies and X-ray structure determination
2024-01-01 Cerchia, Carmen; Laghezza, Antonio; Brunetti, Leonardo; Falbo, Emanuele; Tortorella, Paolo; Piemontese, Luca; Montanari, Roberta; Paoli, Paolo; Jayaprakash, Venkatesan; Loiodice, Fulvio; Lavecchia, Antonio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| (2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone | 1-gen-2021 | Laghezza, A.; Piemontese, L.; Brunetti, L.; Caradonna, A.; Agamennone, M.; Loiodice, F.; Tortorella, P. | |
| 1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease | 1-gen-2022 | Czarnota-Łydka, Kinga; Satała, Grzegorz; Brunetti, Leonardo; Laghezza, Antonio; Piemontese, Luca; DE CANDIA, Modesto; Purgatorio, Rosa; Gumułka, Magdalena; Kucwaj-Brysz, Katarzyna; Carrieri, Antonio; Handzlik, Jadwiga | |
| A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties | 1-gen-2024 | Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Montanari, Roberta; Capelli, Davide; Wackerlig, Judith; Simic, Stefan; Falbo, Emanuele; Pecora, Lucia; Leuci, Rosalba; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Singh, Ravi Pratap; Tambe, Suhas; Sudeep, C. A.; Pattnaik, Ashok Kumar; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio | |
| A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity | 1-gen-2022 | Sblano, S.; Cerchia, C.; Laghezza, A.; Piemontese, L.; Brunetti, L.; Leuci, R.; Gilardi, F.; Thomas, A.; Genovese, M.; Santi, A.; Tortorella, P.; Paoli, P.; Lavecchia, A.; Loiodice, F. | |
| A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION | 1-gen-2023 | Cerchia, C.; Laghezza, A.; Genovese, M.; Leuci, R.; Pranzini, E.; Santi, A.; Brunetti, L.; Piemontese, L.; Tortorella, P.; Biswas, A.; Singh, R. P.; Tambe, S.; Ca, S.; Pattnaik, A. K.; Jayaprakash, V.; Paoli, P.; Loiodice, F.; Lavecchia, A. | |
| A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition | 1-gen-2023 | Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Leuci, Rosalba; Pranzini, Erica; Santi, Alice; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Pratap Singh, Ravi; Tambe, Suhas; Ca, Sudeep; Kumar Pattnaik, Ashok; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio | |
| A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) | 1-gen-2022 | Leuci, R.; Brunetti, L.; Laghezza, A.; Piemontese, L.; Carrieri, A.; Pisani, L.; Tortorella, P.; Catto, M.; Loiodice, F. | |
| A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders | 1-gen-2020 | Leuci, Rosalba; Brunetti, Leonardo; Laghezza, Antonio; Tortorella, Paolo; Loiodice, Fulvio; Piemontese, Luca | |
| Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey | 1-gen-2024 | Brunetti, Leonardo; Francavilla, Fabio; Leopoldo, Marcello; Lacivita, Enza | |
| Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors | 1-gen-2020 | Brunetti, Leonardo; Carrieri, Antonio; Piemontese, Luca; Tortorella, Paolo; Loiodice, Fulvio; Laghezza, Antonio | |
| Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy | 1-gen-2020 | Laghezza, A.; Piemontese, L.; Brunetti, L.; Caradonna, A.; Agamennone, M.; Di Pizio, A.; Pochetti, G.; Montanari, R.; Capelli, D.; Tauro, M.; Loiodice, F.; Tortorella, P. | |
| Can foods influence the onset and progress of neurodegenerative diseases? | 1-gen-2022 | Piemontese, Luca; Brunetti, Leonardo; Leuci, Rosalba | |
| Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases | 1-gen-2024 | Carrieri, Antonio; Barbarossa, Alexia; de Candia, Modesto; Samarelli, Francesco; Damiano Altomare, Cosimo; Czarnota-Łydka, Kinga; Sudoł-Tałaj, Sylwia; Latacz, Gniewomir; Handzlik, Jadwiga; Brunetti, Leonardo; Piemontese, Luca; Limongelli, Francesco; Lentini, Giovanni; Carocci, Alessia | |
| Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease | 1-gen-2020 | Brunetti, Leonardo; Laghezza, Antonio; Loiodice, Fulvio; Tortorella, Paolo; Piemontese, Luca | |
| Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2‐Hydroxyphenylbenzimidazole-based Scaffolds en Route to Donepezil‐Like Compounds | 1-gen-2020 | Piemontese, L.; Sergio, R.; Rinaldo, F.; Brunetti, L.; Perna, F. M.; Amelia Santos, M.; Capriati, V. | |
| Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents | 1-gen-2021 | Poliseno, Viviana; Chaves, Sílvia; Brunetti, Leonardo; Loiodice, Fulvio; Carrieri, Antonio; Laghezza, Antonio; Tortorella, Paolo; Magalhães, João D.; Cardoso, Sandra M.; Santos, M. Amélia; Piemontese, Luca | |
| Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase | 1-gen-2023 | Intranuovo, Francesca; Brunetti, Leonardo; Delre, Pietro; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Laghezza, Antonio; Niso, Mauro; Leonetti, Francesco; Loiodice, Fulvio; Ligresti, Alessia; Kostrzewa, Magdalena; Brea, Jose; Isabel Loza, Maria; Sotelo, Eddy; Saviano, Michele; Colabufo, Nicola Antonio; Riganti, Chiara; Abate, Carmen; Contino, Marialessandra | |
| Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect | 1-gen-2022 | Abatematteo, F. S.; Mosier, P. D.; Niso, M.; Brunetti, L.; Berardi, F.; Loiodice, F.; Contino, M.; Delprat, B.; Maurice, T.; Laghezza, A.; Abate, C. | |
| DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY | 1-gen-2021 | Laghezza, Antonio; Abatematteo, Francesca S.; Mosier, Philip D.; Niso, Mauro; Brunetti, Leonardo; Berardi, Francesco; Loiodice, Fulvio; Contino, Marialessandra; Delprat, Benjamin; Maurice, Tangui; Abate, Carmen | |
| Discovery of a dual PPARα/γ partial agonist displaying antisteatotic and antidiabetic properties: in silico studies and X-ray structure determination | 1-gen-2024 | Cerchia, Carmen; Laghezza, Antonio; Brunetti, Leonardo; Falbo, Emanuele; Tortorella, Paolo; Piemontese, Luca; Montanari, Roberta; Paoli, Paolo; Jayaprakash, Venkatesan; Loiodice, Fulvio; Lavecchia, Antonio |